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Small molecules nanoassemblies-induced aggregation achieves intracellular immobilization of drug-loaded nanoassemblies. In cancer cells, the immobilization of nanoassemblies prolongs the localization of therapeutics inside tumor cells and changes the cell behaviors, e.g., turning the cell apoptosis to immunogenic cell death, thus realizing enhanced immunotherapy, which favors the enhancement of combinational therapy.
