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In vivo dissolution based on ex vivo imaging of residual FNB-HCs. Ex vivo images of the whole isolated GI segments after oral administration of FNB-HCs by gavage (A). Comparison of the in vivo dissolution profile obtained from residual percentage of fluorescent intensity in the stomach (blue line) and the in vitro dissolution (B, red line) and IVIVC established between them (C). Data are expressed as mean ± SD (n = 3).
