Figure 2.

Nano-drug delivery systems and antibody drugs involved caveolin-1-mediated pathways in endothelial cells and tumor cells. (A) Albumin-related nano-drugs pass through adjacent endothelial cells by transcytosis to increase tumor accumulation; (B) Examples of antibody drugs and nano-based drug delivery systems for caveolin-mediated endocytosis to increase antitumor effects. Anti-tumor drugs or certain siRNA or DNA could be encapsulated in specific nanocarriers to enter tumor cells through caveolin-mediated pathways and arrive in ER or Golgi complex and bypass lysosomal degradation during intracellular trafficking. (C) Intracellular biofate of some nano-drugs in caveolin-mediated pathway; (D) Functional polymeric nanoparticles (PBEAGA-CPT) possess rapid extravasation on endothelial cells and rapid transcytosis in tumor cells to achieve deep penetration in tumor cells.