Table 1. Main components and mechanism of action of commercial hemostatic products.
Category | Product Name | Manufacturer | Product type | Main components | Mechanism of action | Ref. |
---|---|---|---|---|---|---|
Inorganic based hemostatic materials | Wound Stat | Unavailable | Hemostatic granules | Smectite | Procoagulant, Mucoadhesive agent | (10) |
Combat Gauze | Z-Medica | Hemostatic gauze | Kaolin | Procoagulant | (11) | |
Quickclot | Z-Medica | Hemostatic granules | Zeolite | Factor concentrators | (12) | |
Polysaccharide based hemostatic materials | Hemcon | HemCon Medical Technologies | Hemostatic bandage | Chitosan | Procoagulant | (13) |
Celox | MedTrade | Hemostatic granules | Cchitosan | Procoagulant | (14) | |
TraumaStat | OreMedix | Hemostatic gauze | Chitosan | Procoagulant | (15) | |
Arista,Hemostase | Bard | Hemostatic microspheres | Starch | Factor concentrators | (16) | |
Surgicel | Johnson & Johnson | Hemostatic gauze | Cellulose | Procoagulant | (17) | |
Traumastem | Baxter | Hemostatic gauze | Cellulose | Procoagulant | (18) | |
Kaltostat | ConvaTec | Hemostatic film | Alginate | Mucoadhesive agent | (19) | |
Sorbalgon | Harmann | |||||
Biologically derived homeostatic materials | Recothrom | ZymoGenetics | Hemostatic solution | Thrombin | Procoagulant | (20) |
Thrombin-JMI | King Pharmaceuticals | Hemostatic powder | Thrombin | Procoagulant | (21) | |
Evithrom | Johnson & Johnson | Hemostatic solution | Thrombin | Procoagulant | (22) | |
Tisseel Evicel | Baxter Ethicon | Sealant | Fibrin | Procoagulant | (23) | |
Vitagel | Stryker | Sealant | Fibrin | Procoagulant | ||
Evarrest | Omrix Biopharmaceuticals | Hemostatic patch | Fibrin | Procoagulant | ||
ARTISS | Baxter | Sealant | Fibrin | Procoagulant | (24) | |
Stypro | Curasan | Hemostatic sponge | Collagen | Factor concentrators, Procoagulant | (25) | |
HEMOBLAST | Biom’Up | Hemostatic powder | Collagen | Procoagulant | (26) | |
Floseal | Baxter | Hemostatic matrix | Gelatin | Procoagulant | (21) | |
Surgiflo | Johnson & Johnson | Hemostatic matrix | Gelatin | Procoagulant | (17) | |
Gelfoam | Pfizer | Hemostatic sponge | Gelatin | Factor concentrators | (27) | |
Lyostypt | Aesculap | Hemostatic Microfibrillar | Microfibrillar Collagen | Procoagulant | (28) | |
Endo-Avitene | Bard | Hemostatic Microfibrillar | Microfibrillar Collagen | Procoagulant | (27) | |
Costasis | Cohesion Technologies | Hemostatic Spray | Microfibrillar Collagen | Procoagulant | (29) | |
Bioglue | CryoLife | Tissue adhesive | Bovine albumin | Mucoadhesive agent | (30) | |
PreveLeak | Baxter | Tissue adhesive | Bovine albumin | Mucoadhesive agent | (31) | |
Synthetically derived hemostatic materials | CoSeal DuraSeal |
Baxter Coviden |
Sealant | Polyethylene glycol | Mucoadhesive agent | (22) |
Dermabond | Johnson & Johnson | Tissue adhesive | Cyanoacrylate | Mucoadhesive agent | (32) | |
Histoacryl | B. Braun Melsungen AG |