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. 2021 Apr 6;96(14):e1865–e1875. doi: 10.1212/WNL.0000000000011700

Figure 3. Periventricular Gradient of Innate Immune Cell Activation in the WM of Patients With MS.

Figure 3

Boxplots represent the percentage of voxels characterized by a significant activation of innate immune cells (DPA+) in (A) the total white matter (WM), (B) the normal-appearing WM, and (C) T2 lesions in patients with multiple sclerosis (MS) (red) and in the WM of healthy controls (blue), calculated in 3-mm-thick concentric rings radiating from the ventricular CSF toward the cortex. Solid lines represent the mixed-effect model fits obtained at the population level for both groups.