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. 2021 Apr;9(8):712. doi: 10.21037/atm-21-1448

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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4-OI reduced inflammation and oxidative stress induced by MRSA in vivo. (A) TNF-α mRNA levels. (B) mRNA levels of IL-1β. (C) mRNA levels of IL-6. (D) MDA content in lung tissue. (E) mRNA levels of Nrf2. (F) mRNA levels of HO-1. (G) mRNA levels of NQO1. Data represent the mean ± standard deviation. Mice in each group =5 (*, P<0.05; **, P<0.01; and ***, P<0.001). 4-OI, 4-octyl itaconate; MRSA, methicillin-resistant Staphylococcus aureus; TNF-α, tumor necrosis factor alpha; MDA, malondialdehyde.