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. 2021 Apr;9(8):713. doi: 10.21037/atm-21-1317

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Differential pathways between astrocytoma and GBM. (A) Principal component analysis was performed in astrocytoma and GBM. The blue dots represent the sample of GBM, and the red dots represent the sample of astrocytoma. (B) Differentially expressed genes (GBM vs. astrocytoma) were analyzed by DESeq2. The upregulated (Log2 fold change ≥1, FDR <0.1) and downregulated (Log2 fold change ≤−1, FDR <0.1) genes were selected and are displayed with a volcano map. The red dots represent the upregulated genes that met the thresholds, and the blue dots represent the downregulated genes that met the thresholds. (C) GO biological process analysis of upregulated genes in GBM. The top10 pathways are shown with red bars. (D) GO biological process analysis of upregulated genes in astrocytoma. The top 10 pathways are shown with blue bars. GBM, glioblastoma; GO, Gene Ontolgoy.