Table 5. Univariate and multivariate analysis of the factors, including TDs status (=1 or =2–4 or ≥5) CSS for TDs+ CRC with stage III.
| Characteristics | Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | ||
| Sex | |||||||
| Female | 1 | 1 | |||||
| Male | 0.85 | 0.74–0.98 | 0.021 | 0.93 | 0.81–1.07 | 0.312 | |
| Race | |||||||
| White | 1 | ||||||
| Black | 1.13 | 0.91–1.39 | 0.268 | ||||
| Other | 0.94 | 0.75–1.18 | 0.575 | ||||
| Age at diagnosis, years | |||||||
| <65 | 1 | 1 | |||||
| ≥65 | 2.50 | 2.15–2.92 | <0.001 | 2.06 | 1.75–2.43 | <0.001 | |
| Tumor location | |||||||
| Left | 1 | 1 | |||||
| Right | 1.44 | 1.25–1.66 | <0.001 | 1.05 | 0.91–1.21 | 0.531 | |
| Histological grade | |||||||
| Well | 1 | 1 | |||||
| Moderate | 0.88 | 0.64–1.21 | 0.430 | 0.87 | 0.63–1.20 | 0.410 | |
| Poorly | 1.37 | 0.98–1.92 | 0.066 | 1.02 | 0.72–1.43 | 0.921 | |
| Undifferentiated | 2.00 | 1.33–2.99 | 0.001 | 1.58 | 1.05–2.39 | 0.029 | |
| Pathological type | |||||||
| Adenocarcinoma | 1 | 1 | |||||
| Mucinous adenocarcinoma | 1.29 | 1.02–1.63 | 0.031 | 1.11 | 0.87–1.40 | 0.398 | |
| Signet-ring cell carcinoma | 2.19 | 1.36–3.55 | 0.001 | 1.20 | 0.72–1.98 | 0.485 | |
| AJCC 8th T | |||||||
| T1 | 1 | 1 | |||||
| T2 | 0.92 | 0.41–2.06 | 0.846 | 0.88 | 0.39–1.98 | 0.763 | |
| T3 | 2.28 | 1.13–4.59 | 0.021 | 1.77 | 0.88–3.56 | 0.112 | |
| T4 | 4.90 | 2.43–9.90 | <0.001 | 3.56 | 1.76–7.22 | 0.001 | |
| AJCC 8th N | |||||||
| N1 | 1 | 1 | |||||
| N2 | 1.88 | 1.63–2.17 | <0.001 | 1.89 | 1.62–2.20 | <0.001 | |
| TDs | |||||||
| 1 | 1 | 1 | |||||
| 2–4 | 1.44 | 1.23–1.67 | <0.001 | 1.36 | 1.16–1.59 | 0.001 | |
| ≥5 | 2.15 | 1.76–2.63 | <0.001 | 1.75 | 1.43–2.16 | <0.001 | |
| Chemotherapy | |||||||
| None/unknown | 1 | 1 | |||||
| Yes | 0.42 | 0.37–0.49 | <0.001 | 0.44 | 0.38–0.51 | <0.001 | |
TD, tumor deposits; CRC, colorectal cancer; CSS, cancer-specific survival.