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Organ-specific tumor responses. (A) Best reduction from baseline in liver tumors and extrahepatic metastases. (B) Representative images showing response in brain metastasis in one patient: shrinkage of brain metastasis with intra-tumor hemorrhage from baseline (left panel) to follow-ups after lenvatinib plus 2 cycles (middle panel) and 4 cycles (right panel) of sintilimab. The arrows indicate brain metastasis.
