Figure 1.

Effects of protocatechualdehyde (PCA) on body weight (A) and fasting plasma glucose (FPG) (B). SD rats were intraperitoneally injected with a single dose of streptozotocin (STZ) (60 mg/kg body weight). One week later, rats displaying FPG ≥250 mg/dL were taken to be diabetic rats and were included in subsequent experiments. Control and hyperglycemic rats were randomly assigned to 4 groups (n=12 each group): the untreated control group (Con), the PCA-treated Con group (Con + PCA), the untreated STZ-induced diabetic group (STZ), the and PCA-treated STZ group (STZ + PCA). Rats in the two treatment groups were administered PCA via gavaging at a dose of 25 mg/kg/day for 6 weeks. Values are displayed as mean ± SD, n=12 per group. *P<0.05 vs. Con rats.