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. 2021 Apr;9(8):684. doi: 10.21037/atm-21-1070

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Effects of SNO on macrophage Kupffer activation by regulating PPARγ/SFRP5 pathway in L02 hepatocytes. (A,B) The expression levels of PPARγ and SFRP5 protein in L02 cells; (C,D) the levels of TNFα, IL-1β, and IL-6 secreted by macrophage Kupffer cells. *P<0.05 vs. NC group; aP<0.05 vs. GSNO/1,400 W group; bP<0.05 vs. pcDNA/sh-PPARγ group; cP<0.05 vs. pcDNA/sh-SFRP5 group. NC, negative control; PPARγ, peroxisome proliferators-activated receptors γ; SFRP5, secreted frizzled related protein 5; SNO, S-nitrosylation; GSNO, SNO enhancer S-Nitrosoglutathione; TNFα, tumor necrosis factor α; IL-1β, interleukin-1β; IL-6, interleukin-6.