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. 2021 May 7;40:157. doi: 10.1186/s13046-021-01964-0

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© The Author(s) 2021, corrected publication 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — miR-455-5p was reduced in MTC and overexpression of miR-455-5p suppressed MTC cell proliferation, migration, and invasion. a Relative miR-455-5p levels in MTC tissues and adjacent non-tumor tissues. b Survival rate in patients with high miR-455-5p level and low miR-455-5p level. c Relative miR-455-5p levels in MTC cells. d Relative miR-455-5p levels in MTC cells transfected with mimics NC or miR-455-5p mimics. e & f Representative images of colonies formed in mimics NC transfected or miR-455-5p mimics transfected MTC cells. g Flow cytometry analysis of the number of transfected cells in G1, S, and G2 phases. h Flow cytometry analysis of cell apoptosis in MTC cells transfected with mimics NC or miR-455-5p mimics. i & j Transwell assay to quantify the migration and invasion abilities of transfected cells. k & l EMT-related protein levels in transfected MTC cells. * P < 0.05; ** P < 0.01; *** P < 0.001