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. 2021 May 7;40:157. doi: 10.1186/s13046-021-01964-0

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© The Author(s) 2021, corrected publication 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — miR-455-5p suppressed CXCL12 signaling via targeting CXCL12. a Complementary binding sites between CXCL12 3’ UTR and miR-455-5p. b Relative CXCL12 mRNA levels in MTC tissues. c Correlation between miR-455-5p level and CXCL12 mRNA level in MTC tissues. d Relative CXCL12 mRNA level in MTC cells. e Relative CXCL12 mRNA level in mimics NC transfected or miR-455-5p mimics transfected MTC cells. f & g Relative CXCL12 protein level in mimics NC transfected or miR-455-5p mimics transfected MTC cells. h Relative luciferase activity in transfected MTC cells. *P < 0.05; ** P < 0.01; *** P < 0.001