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. 2021 May 8;10:76. doi: 10.1186/s13756-021-00947-2

Table 1.

Definitions used for the classification of drug susceptibility profiles of patients with rifampicin-resistant tuberculosis, Uganda, 2014–2018

Variable Definition
Rifampicin resistance (RR) Resistance to rifampicin detected using phenotypic or genotypic methods, with or without resistance to other anti-TB drugs. It includes any resistance to rifampicin, in the form of monoresistance, polyresistance, MDR or XDR
Monoresistance Resistance to one first-line anti-TB drug only (streptomycin, rifampicin, isoniazid, ethambutol, pyrazinamide)
Polydrug resistance Resistance to more than one first-line anti-TB drug (other than both isoniazid and rifampicin)
Multidrug resistance (MDR) Resistance to at least both isoniazid and rifampicin
Pre-extensively drug-resistant tuberculosis (Pre-XDR TB) MDR-TB with resistance to fluoroquinolones (ofloxacin, levofloxacin and moxifloxacin) or a second-line injectable (amikacin, kanamycin, or capreomycin), but not both
Extensively drug resistant TB (XDR TB) Resistance to isoniazid and rifampin plus resistance to any fluoroquinolone (ofloxacin, levofloxacin and moxifloxacin) and at least one of three injectable second-line drugs (i.e., amikacin, kanamycin, or capreomycin)