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a Graphical representation of different melanoma types. b Different mechanisms underlying angiogenesis and vasculogenic mimicry in CM, UM and MM. In angiogenesis, cancer cells secrete angiogenic factors and promote the development of new endothelial cell-lined blood vessels from pre-existing normal blood vessels. Conversely, in vasculogenic mimicry tumor cells mimic the presence and function of endothelial cells, forming capillary-like structures
