Table 4.
ICAM1, MELD and organ failures as independent mortality predictors in patients with cirrhosis and severe COVID-19 or sepsis in the intensive care unit.
| Risk factor | Univariate analysis |
|
|---|---|---|
| HR (95% CI) | p value | |
| Age | 0.98 (0.96-1.01) | 0.44 |
| Sex | 0.72 (0.2-2.43) | 0.59 |
| CCI score | 1.03 (0.78-1.38) | 0.79 |
| D-dimers# | 2.89 (0.40-20.45) | 0.28 |
| Ferritin | 1.08 (0.66-1.76) | 0.75 |
| LDH# | 1.51 (0.78-2.90) | 0.213 |
| NLR | 1.05 (1.00-1.11) | 0.04∗ |
| PCT | 0.94 (0.83-1.07) | 0.41 |
| Albumin | 1.13 (0.59-2.188) | 0.69 |
| Bilirubin | 1.03 (0.99-1.08) | 0.08 |
| Sodium | 1 (0.95-1.04) | 0.97 |
| AST# | 1.86 (1.04-3.31) | 0.03∗ |
| ALT# | 1.17 (0.59-2.30) | 0.64 |
| INR | 1.25 (0.81-1.92) | 0.3 |
| Creatinine | 1.26 (1.03-1.54) | 0.02∗ |
| Child-Pugh | 1.08 (0.91-1.28) | 0.37 |
| MELD | 1.066 (1.01-1.11) | 0.007∗ |
| Liver Failure | 1.68 (0.75-3.78) | 0.2 |
| Renal Failure | 3.41 (1.23-9.47) | 0.018∗ |
| Respiratory Failure | 0.93 (0.31-2.77) | 0.9 |
| Circulatory Failure | 1.06 (0.46-2.43) | 0.87 |
| Coagulation Failure | 3.22 (1.35-7.66) | 0.008∗ |
| CLIF-OF | 1.29 (1.10-1.52) | 0.002∗ |
| SOFA | 1.47 (1.12-1.93) | 0.005∗ |
| ARDS | 1.06 (0.47-2.38) | 0.87 |
| ICAM1# | 2.68 (1-7.21) | 0.04∗ |
| vWF# | 1.02 (0.53-1.96) | 0.94 |
| Vegfr1# | 0.95 (0.45-2.02) | 0.9 |
| Ang1# | 1.49 (0.86-2.59) | 0.14 |
| Ang2# | 0.93 (0.57-1.52) | 0.79 |
| Multivariate analysis (without inclusion of organ failures and composite scores) | ||
| ICAM1# | 2.92 (1.02-8.31) | 0.04 |
| MELD | 1.07 (1.02-1.11) | 0.006 |
| AST# | 2.17 (1.15-4.11) | 0.02 |
| Multivariate analysis (with inclusion of various organ failures and not composite scores) | ||
| ICAM1# | 3.24 (1.19-8.86) | 0.02 |
| Renal failure | 4.57 (1.54-13.6) | 0.006 |
| Coagulation failure | 2.79 (1.08-9.7.15) | 0.03 |
| Multivariate Analysis (with inclusion of composite scores without individual organ failures) | ||
| SOFA | 1.47 (1.12-1.93) | 0.005 |
| CLIF-OF | 1.29 (1.10-1.53) | 0.002 |
Significance was taken as p <0.05. CCI, Charlson comorbidity index; CLIF-OF, chronic liver failure-organ failure; HR, hazard ratio; LDH, lactate dehydrogenase; MELD, model for end-stage liver disease; NLR, neutophil to lymphocyte ratio; PCT, procalcitonin; SOFA, sequential organ failure assessment.
#
Log values of these parameters were taken.
∗
Denotes significant p values (Cox regression).