Table 2.

Mutation signature examples selected by the LASSO algorithm (16)

	1	2	3	4
	Dataset 1 (incl. age)a	Dataset 2	Dataset 2 (incl. age)	Dataset 2
Performanceb	AUC = 0.938; Accuracy (ACC) = 0.866	AUC = 0.887; ACC = 0.800	AUC = 0.933; ACC = 0.836	AUC = 0.893; ACC = 0.806
1	Spike_V1176F	Spike_V1176F	Spike_V1176F	Spike_V1176F
2	N_I292T	N_I292T	NS3_Q57H	NS3_Q57H
3	NS3_Q57H	Spike_L5F	N_I292T	NSP4_M324I
4	SG29830T	NSP3_A994D	N_D377Y	NSP12_P323L
5	SC241T	NS3_Q57H	N_S194L	Spike_D614G
6	N_D377Y	NSP14_A320V	Spike_D614G	NSP13_S485L
7	NSP4_F308Y	N_S194L	NSP13_H290Y	N_I292T
8	NS3_G251S	NSP6_L37F	N_G204R	Spike_L5F
9	NSP6_L37F	SC241Tc	NS3_G251V	NSP4_F308Y
10	NSP4_M324I	N_G204R	NSP14_A320V	N_S194L
11	N_M234I	SG29830Tc	N_M234I	N_G204R
12	NSP13_H290Y	Spike_D614G	NSP4_F308Y	NSP3_A994D
13	NSP14_A320V	NSP13_S485L	SG29830Tc	NSP6_L37F
14	N_S194L	NSP4_F308Y	NSP12_P323L	SC241Tc
15	NSP7_S25L	NSP4_M324I	Spike_L5F	NSP3_K945N
16		N_D377Y	NSP6_L37F	NSP7_S25L
17		NSP7_S25L	NSP4_M324I	NS3_G251S
18		NS3_G251V	SC241Tc	SG29830Tc
19		N_M234I	NS8_L84S	NS3_G251V
20		NS3_G251S		NSP14_A320V
21				NSP13_H290Y
22				N_D377Y
23				Spike_N439K
24				NS8_L84S
25				NSP3_I1683T

^a Determined on datasets described in the Materials and methods section. The learning procedure only included patient age if indicated.

^b Corrected AUC values.

^c UTR mutations.