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. 2021 May 3;15:1835–1849. doi: 10.2147/DDDT.S300376

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© 2021 Zhang et al.

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Circ-XIAP directly interacted with miR-1182. (A) The binding sequence between circ-XIAP and miR-1182 was shown. (B and C) The luciferase activity in DU145/DTX and PC3/DTX cells co-transfected with WT-circ-XIAP/MUT-circ-XIAP and miR-1182/miR-NC was detected. (D) MiR-1182 level in DTX-resistant tissues and DTX-sensitive tissues was measured. (E) MiR-1182 expression was analyzed in RWPE-1, DU145, DU145/DTX, PC3, and PC3/DTX cells. (F) The association between the levels of miR-1182 and circ-XIAP in DTX-resistant tissues was analyzed. (G) The abundance of miR-1182 was detected in DU145/DTX and PC3/DTX cells after transfection with si-NC, si-circ-XIAP, vector, or circ-XIAP. **P<0.01, ***P<0.001, ****P<0.0001.