Table 6.
Levels of IL-6, IL-10, IL-12, IL-1β, TNF-α and IFN-γ in Serum and Liver Tissue of Mice (N=10/Group)
| Groups | IL-6 | IL-10 | IL-12 | IL-1β | TNF-α | IFN-γ | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Serum (pg/mL) |
Liver (pg/mgprot) |
Serum (pg/mL) |
Liver (pg/mgprot) |
Serum (pg/mL) |
Liver (pg/mgprot) |
Serum (pg/mL) |
Liver (pg/mgprot) |
Serum (pg/mL) |
Liver (pg/mgprot) |
Serum (pg/mL) |
Liver (pg/mgprot) |
|
| Normal | 11.36±0.53cA | 4.58±0.09c | 122.60±3.93a | 125.36±1.52b | 3.28±0.06a | 9.14±0.16d | 11.99±0.41d | 13.66±0.48c | 49.21±1.05b | 94.01±3.47d | 95.92±7.63b | 83.9±1.59b |
| Model | 14.52±0.38a | 6.87±0.21a | 93.61±6.72d | 97.17±6.9d | 2.77±0.03c | 12.45±0.31a | 18.82±0.47a | 18.1±0.59a | 61.87±2.94a | 115.99±4.11a | 152.49±7.13a | 95.31±2.6a |
| Silymarin-L | 12.49±0.48b | 5.7±0.22b | 102.32±3.26c | 107.65±4.05c | 2.81±0.04c | 10.53±0.07b | 16.68±0.44b | 17±0.39b | 60.74±2.99a | 109.39±2.42b | 92.49±3.94b | 93.1±7.33a |
| Silymarin-H | 10.28±0.21d | 4.64±0.15c | 111.84±3.85b | 157.43±3.44a | 3.15±0.06b | 9.75±0.33c | 13.67±0.35c | 11.76±0.38d | 49.32±2.37b | 100.9±2.51c | 69.67±6.17c | 75.88±5.5b |
Notes: Model, treated with D-Gal/LPS (250 mg/kg·bw and 25 mg/kg·bw) injection; silymarin-L: treated with silymarin (75 mg/kg·bw) oral administration; silymarin-H: treated with silymarin (150 mg/kg·bw) oral administration. a–dThere was significant difference in different letters in the same column (P < 0.05), which was determined by Duncan’s multiple range test. AValues presented are the mean±standard deviation (SD) of different organ coefficients.