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. 2021 Mar 5;49(2):893–901. doi: 10.1042/BST20200835

Figure 2. Substrate specificity and subcellular localization of phosphoinositides produced by PI3K isoforms.

Figure 2.

(A) Upstream activating input into distinct classes of PI3Ks and their downstream effector domains/proteins are shown. (B) Subcellular distribution of the distinct PI3K isoform-generated phosphoinositides is shown. The three classes of PI3K specifically generate sub-compartmentally localized 3′-phosphoinositide pools. Only PI(3,4,5)P3 is produced by class I PI3Ks in the plasma membrane, whereas both PI(3,4)P2 and PI(3)P are generated by class II and III PI3Ks, forming distinct cellular pools mainly involved in endo-lysosomal and autophagy pathways.