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. 2020 Sep 15;12(5):394–410. doi: 10.1007/s13238-020-00784-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Microbiota-based integrated multi-omics platforms for TCM-derived herb study.

The basic rationale is to identify TCM herbs related active components after transformation by gut microbiota fermentation. The multiomics platforms such as, epigenetics, 16s metagenomics, shotgun metagenomics, transcriptomics, proteomics, and metabolomics are to be used, followed by the integrated analysis. Such strategy may identify novel TCM prebiotics, bacteria (probiotics) and metabolites (postbiotics) as well as bacterial structural components (paraprobiotics) to modulate local intestine and systematic target organs in hosts for disease amelioration