Table 3.
Cotwin control analysis between alcohol use (drink index) and cortical thickness.
| Cotwin control | ||||||
|---|---|---|---|---|---|---|
| Within-pair | Between-pair | |||||
| Area | Beta (SE) | t (df) | p-value | Beta (SE) | t (df) | p-value |
| Control A | ||||||
| PFCl | −0.081 (0.026) | −3.096 (185) | 0.0023 | −0.051 (0.025) | −2.059 (179) | 0.0409 |
| IPS | −0.040 (0.024) | −1.629 (185) | 0.1050 | −0.047 (0.020) | −2.348 (179) | 0.0200 |
| Control B | ||||||
| PFCld | −0.052 (0.032) | −1.608 (185) | 0.1096 | −0.111 (0.031) | −3.616 (179) | 0.0004 |
| PFClv | −0.033 (0.033) | −0.964 (185) | 0.3363 | −0.125 (0.037) | −3.390 (179) | 0.0009 |
| PFCmp | −0.017 (0.019) | −0.935 (185) | 0.3509 | −0.044 (0.018) | −2.462 (179) | 0.0148 |
| Temp | −0.058 (0.039) | −1.509 (185) | 0.1331 | −0.092 (0.028) | −3.330 (179) | 0.0011 |
| Control C | ||||||
| pCun | −0.035 (0.027) | −1.319 (185) | 0.1888 | −0.080 (0.023) | −3.430 (179) | 0.0007 |
| Salience A | ||||||
| FrMed | −0.113 (0.049) | −2.285 (185) | 0.0234 | −0.205 (0.054) | −3.825 (179) | 0.0002 |
| FrOper | −0.031 (0.013) | −2.431 (185) | 0.0160 | −0.012 (0.012) | −0.945 (179) | 0.3458 |
| Ins | −0.021 (0.018) | −1.151 (185) | 0.2514 | −0.018 (0.015) | −1.176 (179) | 0.2412 |
| ParMed | −0.068 (0.027) | −2.547 (185) | 0.0117 | −0.063 (0.026) | −2.443 (179) | 0.0156 |
| ParOper | 0.006 (0.018) | 0.349 (185) | 0.7278 | −0.040 (0.014) | −2.845 (179) | 0.0050 |
| Salience B | ||||||
| PFCl | −0.032 (0.023) | −1.411 (185) | 0.1599 | −0.052 (0.020) | −2.560 (179) | 0.0113 |
| PFClv | −0.027 (0.016) | −1.627 (185) | 0.1054 | −0.025 (0.013) | −1.954 (179) | 0.0523 |
| PFCmp | −0.015 (0.014) | −1.065 (185) | 0.2881 | −0.036 (0.013) | −2.806 (179) | 0.0056 |
Notes: Significant effects (p < 0.05) are in bold. Cortical thickness was summed across parcels within the same network and cortical regions that showed significant individual-level associations with alcohol (e.g., the three Control A PFCl parcels in Table 2) prior to the cotwin control analysis to reduce multiple comparisons.
Abbreviations: PFC, prefrontal cortex; IPS, intraparietal sulcus; Temp, temporal; pCun; precuneus; FrMed, frontal medial; FrOper, frontal operculum; Ins, insula; ParMed, parietal medial; ParOper, parietal operculum; l, lateral; d, dorsal; v, ventral; mp, medial posterior.