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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Curr Opin Chem Biol. 2021 Mar 11;61:170–178. doi: 10.1016/j.cbpa.2021.01.015

Figure 3.

Figure 3.

New tools to study ferrous iron in vitro and in vivo. (a) RhoNox-family probes are activated by reduction of an N-oxide bond; (b) TRX-based probes are activated by reduction of a hindered peroxide bond; (c) The probe ICL-1 releases D-aminoluciferin and can be used in luciferin-expressing cells and animals; (d) mice infected with A. baumannii show elevated Fe2+ as detected with ICL-1; (e) the drug conjugate TRX-PF508 releases an LpxC inhibitor upon sensing Fe2+ in vivo and is efficacious in an acute P. aeruginosa lung infection model.