TABLE 7.
Antibiotic resistance gene detection in the prospective and archived arms
| Type of resistance | Resistance gene | Study arma | No. positive/no. reported (%)b | No. confirmed by PCR followed by sequencing/no. positive (%) |
|---|---|---|---|---|
| Resistance to 3rd-generation cephalosporins in Enterobacterales, P. aeruginosa, or Acinetobacter species | blaCTX-M | Prospective | 9/208 (4.3) | 8/9 |
| Archived | 14/212 (6.6) | 14/14 | ||
| Total | 23/420 (5.5) | 22/23 (95.7) | ||
| Resistance to carbapenems in Enterobacterales, P. aeruginosa, or Acinetobacter speciesc | blaKPC | Prospective | 4/208 (1.9) | 4/4 |
| Archived | 2/212 (0.9) | 2/2 | ||
| Total | 6/420 (1.4) | 6/6 (100.0) | ||
| blaNDM | Prospective | 1/208 (0.5) | 1/1 | |
| Archived | 0/212 (0.0) | |||
| Total | 1/420 (0.2) | 1/1 (100.0) | ||
| blaVIM | Prospective | 1/208 (0.5) | 1/1 | |
| Archived | 0/212 (0.0) | |||
| Total | 1/420 (0.2) | 1/1 (100.0) | ||
| blaOXA-48 | Prospective | 1/112 (0.9) | 1/1 | |
| Archived | 0/166 (0.0) | |||
| Total | 1/278 (0.4) | 1/1 (100.0) | ||
| Resistance to carbapenems in Acinetobacter species conferred by blaOXA panel markers | blaOXA-23 | Prospective | 3/21 (14.3) | 3/3 |
| Archived | 4/21 (19.0) | 4/4 | ||
| Total | 7/42 (16.7) | 7/7 (100.0) | ||
| blaOXA-24 | Prospective | 4/21 (19.0) | 4/4 | |
| Archived | 3/21 (14.3) | 3/3 | ||
| Total | 7/42 (16.7) | 7/7 (100.0) | ||
| blaOXA58 | Prospective | 0/21 (0.0) | ||
| Archived | 1/21 (4.8) | 1/1 | ||
| Total | 1/42 (2.4) | 1/1 (100.0) | ||
| Resistance to penicillin in H. influenzae | blaTEM | Prospective | 16/56 (28.6) | 15/16 |
| Archived | 24/71 (33.8) | 23/24 | ||
| Total | 40/127 (31.5) | 38/40 (95.0) | ||
| Resistance to oxacillin (methicillin) in S. aureus | mecA | Prospective | 47/104 (45.2) | 32/47 |
| Archived | 44/77 (54.1) | 34/44 | ||
| Total | 91/181 (50.3) | 66/91 (72.5) | ||
a
Prospective study arm, n = 1,016; archived study arm, n = 392.
b
Unyvero reports results for antibiotic resistance markers only if one or more corresponding host organism(s) is simultaneously detected (otherwise, marker results are masked).
c
The carbapenem markers blaKPC, blaNDM, and blaVIM are associated with Enterobacterales, P. aeruginosa, or Acinetobacter species (420 reported results for the prospective and archived study arms), while blaoxa-48 is associated with Enterobacterales only (278 reported results for the prospective and archived study arms).