TABLE 2.
Microbiological and clinical profiles of nontoxigenic and toxigenic C. diphtheriae, C. belfantii, and C. ulcerans isolates in Spain, 2014 to 2019
| Characteristic | Total no. (%) of isolates (n = 39) | No. (%) of nontoxigenic isolates (n = 30) | No. (%) of toxigenic isolates (n = 9) |
|---|---|---|---|
| Type and subtype | |||
| C. diphtheriae | 21 (54) | 15 (50) | 6 (67) |
| Gravis | 7 (18) | 7 (23) | 0 (0) |
| Mitis | 13 (33) | 8 (27) | 5 (56) |
| Undetermineda | 1 (3) | 0 (0) | 1 (11) |
| C. belfantii | 14 (36) | 14 (47) | 0 (0) |
| C. ulcerans | 4 (10) | 1 (3) | 3 (33) |
| Antimicrobial resistancea | |||
| Penicillin G | |||
| Resistant (>0.125 mg/liter) | 29 (76) | 23 (77) | 6 (75) |
| Susceptible (≤0.125 mg/liter) | 9 (24) | 7 (23) | 2 (25) |
| Erythromycin | |||
| Resistant (>2 mg/liter) | 0 (0) | 0 (0) | 0 (0) |
| Intermediate (1 mg/liter) | 0 (0) | 0 (0) | 0 (0) |
| Susceptible (≤0.5 mg/liter) | 38 (100) | 30 (100) | 8 (100) |
| Sample type | |||
| Respiratory | 21 (54) | 18 (60) | 3 (33) |
| Cutaneous | 16 (41) | 10 (33) | 6 (67) |
| Other | 2 (5) | 2 (7) | 0 (0) |
a
One patient had undetermined subtype and antimicrobial resistance because of starting the antibiotic treatment prior to the specimen collection, therefore n = 38 in antimicrobial resistance.