TABLE 1.
M. tuberculosis isolate panel used to determine the accuracy of detection of rifampicin and isoniazid resistance
| Drug | Gene | Mutation | No. of strains included in the study | Estimated global frequency in resistant isolates (%)a |
|---|---|---|---|---|
| Isoniazid | katG | S315N | 1 | 3.26 |
| S315T | 16 | 67.28 | ||
| fabG1 promoter region | −15C/T | 5 | 19.26 | |
| Rifampicin | rpoB | S450L | 5 | 55.46 |
| S450W | 1 | 1.66 | ||
| S450F | 1 | 0.13 | ||
| Q432P | 1 | 0.54 | ||
| D435V | 1 | 6.45 | ||
| D435G | 1 | 2.09 | ||
| D435F | 1 | 0.47 | ||
| S441L | 1 | 0.51 | ||
| H445D | 1 | 3.97 | ||
| H445L | 1 | 1.46 | ||
| H445R | 2 | 2.12 | ||
| H445Y | 1 | 6.72 | ||
| H445G | 1 | 0.13 | ||
| L452P | 1 | 3.61 | ||
| Q432–433 insertion | 1 | 0.00084 | ||
a
See reference 21.