TABLE 2.
Limit of detection as determined for each platform for MTBC detection
| Mycobacterium | Limit of detection (no. of genomes/ml) at a 95% hit rate (95% CI) for MTBC detectiona |
||||
|---|---|---|---|---|---|
| Comparator assay (Xpert MTB/RIF) | Centralized assays |
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| Abbott RealTime MTB | BD Max MDR-TB | Roche cobas MTB | Hain Lifescience FluoroType MTBDR | ||
| M. tuberculosis H37Rv | 3,781b (1,974–5,589) | 322 (211–432) | 826b,c (592–1,060) | 2,416 (858–3,974) | 10,398b (6,380–14,416) |
| M. bovis | 2,926b (1,991–3,861) | 2,182 (1,467–2,897) | 4,301b,c (3,048–5,555) | 2,136b (664–3,607) | 23,139b (15,832–30,446) |
a
CI, confidence interval.
b
No tested dilution had 0% detection.
c
No tested dilution had 100% detection.