TABLE 4.

Accuracy for the detection of specific mutations conferring resistance to rifampicin and isoniazid^a

Drug	Target	Mutation	Frequency (%)b	No. of strains	No. of replicates	Abbott RealTime MTB RIF/INH			BD Max MDR-TB			Hain FluoroType MTBDR			Roche cobas MTB-RIF/INH			Genotype MTBDRplus
						No. detected	Spi (%)	Swi (%)	No. detected	Spi (%)	Swi (%)	No. detected	Spi (%)	Swi (%)	No. detected	Spi (%)	Swi (%)	No. detected	Spi (%)	Swi (%)
Isoniazid	katG	S315T	67.68	16	48	48	100	67.68	48	100	67.68	48	100.0	67.68	NA	NA	NA	16	100	67.68
		S315N	3.26	1	3	3	100	3.26	0	0	0	0	0.0	0	NA	NA	NA	1	100	3.26
	fabG1c	−15C/T	19.26	5	15	15	100	19.26	15	100	19.3	15	100.0	19.26	NA	NA	NA	5	100	19.26
Rifampicin	rpoB	S450L	55.46	5	15	15	100	55.46	15	100	55.5	15	100.0	55.46	15	100	55.46	5	100	55.46
		H445Y	6.72	1	3	3	100	6.72	3	100	6.72	3	100.0	6.72	3	100	6.72	1	100	6.72
		D435V	6.45	1	3	3	100	6.45	3	100	6.45	3	100.0	6.45	3	100	6.45	1	100	6.45
		H445D	3.97	1	3	3	100	3.97	3	100	3.97	3	100.0	3.97	3	100	3.97	1	100	3.97
		L452P	3.61	1	3	3	100	3.61	3	100	3.61	3	100.0	3.61	3	100	3.61	1	100	3.61
		H445R	2.12	2	6	0	0	0	6	100	2.12	5	83.3	1.77	6	100	2.12	1	50	1.06
		D435G	2.09	1	3	0	0	0	3	100	2.09	3	100.0	2.09	3	100	2.09	1	100	2.09
		S450W	1.66	1	3	3	100	1.66	3	100	1.66	2	66.7	1.11	3	100	1.66	1	100	1.66
		H445L	1.46	1	3	3	100	1.46	3	100	1.46	3	100.0	1.46	3	100	1.46	1	100	1.46
		Q432P	0.54	1	3	3	100	0.54	3	100	0.54	3	100.0	0.54	3	100	0.54	1	100	0.54
		S441L	0.51	1	3	0	0	0	3	100	0.51	3	100.0	0.51	3	100	0.51	1	100	0.51
		D435F	0.47	1	3	3	100	0.47	3	100	0.47	3	100.0	0.47	0	0	0	1	100	0.47
		S450F	0.13	1	3	3	100	0.13	3	100	0.13	3	100.0	0.13	3	100	0.13	1	100	0.13
		H445G	0.13	1	3	3	100	0.13	3	100	0.13	3	100.0	0.13	3	100	0.13	1	100	0.13
		Q432–433 insertion	<0.01	1	3	3	100	<0.01	3	100	<0.01	3	100.0	<0.01	0	0	0	1	100	<0.01

^aS_pi, S_p per individual mutation; S_wi, S_w per individual mutation.

^bFrequency of mutation in resistant strain (21).

^cfabG1 promoter region.