TABLE 5.
Positive and negative predictive values of serological assays at ≥15 days after symptom onset as a function of COVID-19 seroprevalence
| Assays | % Se | % Sp | % PPV for COVID seroprevalence of: |
% NPV for COVID seroprevalence of: |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1% | 5% | 10% | 15% | 1% | 5% | 10% | 15% | |||
| Beckman Coulter IgG | 74 | 100 | 100.0 | 100.0 | 100.0 | 100.0 | 99.7 | 98.7 | 97.2 | 95.6 |
| Bio-Rad total Ab | 90 | 97 | 23.3 | 61.2 | 76.9 | 84.1 | 99.9 | 99.5 | 98.9 | 98.2 |
| Abbott IgG | 83 | 100 | 100.0 | 100.0 | 100.0 | 100.0 | 99.8 | 99.1 | 98.1 | 97.1 |
| DiaSorin IgG | 82 | 100 | 100.0 | 100.0 | 100.0 | 100.0 | 99.8 | 99.1 | 98.0 | 96.9 |
| Ortho-Clinical IgG | 84 | 99 | 45.9 | 81.6 | 90.3 | 93.7 | 99.8 | 99.2 | 98.2 | 97.2 |
| Ortho-Clinical total Ab | 93 | 100 | 100.0 | 100.0 | 100.0 | 100.0 | 99.9 | 99.6 | 99.2 | 98.8 |
| Siemens total Ab | 85 | 99 | 46.2 | 81.7 | 90.4 | 93.8 | 99.8 | 99.2 | 98.3 | 97.4 |
| Euroimmun IgA | 89 | 84 | 5.3 | 22.6 | 38.2 | 49.5 | 99.9 | 99.3 | 98.6 | 97.7 |
| Euroimmun IgG | 81 | 94 | 12.0 | 41.5 | 60.0 | 70.4 | 99.8 | 98.9 | 97.8 | 96.6 |
| Roche total Ab | 85 | 100 | 100.0 | 100.0 | 100.0 | 100.0 | 99.8 | 99.2 | 98.4 | 97.4 |
| Biocan IgM, IgG | 84 | 99 | 45.9 | 81.6 | 90.3 | 93.7 | 99.8 | 99.2 | 98.2 | 97.2 |
| BTNX IgM, IgG | 91 | 87 | 6.6 | 26.9 | 43.8 | 55.3 | 99.9 | 99.5 | 98.9 | 98.2 |
| NADAL IgM, IgG | 95 | 98 | 32.4 | 71.4 | 84.1 | 89.3 | 99.9 | 99.7 | 99.4 | 99.1 |