TABLE 3.
Characteristic | IE PSt/PK fat | Non-IE PSt/PK fat | RO (reference) | Treatment effect (P value) | Mean difference IE – non-IE | Mean difference IE – RO | Mean difference non-IE – RO |
---|---|---|---|---|---|---|---|
iAUC(0–8 h), mmol/L⋅h | 3.80 (2.33, 5.27) | 3.61 (3.02, 4.20)2 | 5.28 (4.08, 6.47)2 | 0.040 | 0.20 (–1.75, 2.14) | –1.47 (–3.74, 0.79) | –1.673 (–3.29, –0.04) |
iAUC(0–4 h), mmol/L⋅h | 0.80 (0.30, 1.30) | 0.88 (0 .61, 1.16) | 1.82 (1.37, 2.27) | 0.0002 | –0.09 (–0.72, 0.55) | –1.024 (–1.73, –0.31) | –0.945 (–1.43, –0.45) |
Cmax, mmol/L | 2.28 (1.97, 2.59) | 2.26 (2.10, 2.41) | 2.66 (2.31, 3.00) | 0.058 | 0.02 (–0.36, 0.40) | –0.38 (–0.89, 0.14) | –0.40 (–0.81, 0.01) |
Tmax, h | 5 (4, 6) | 5 (5, 5) | 5 (4, 5) | 0.3346 | NA | NA | NA |
Values are estimated marginal means with baseline values as a covariate, apart from Tmax, which are medians with limits of lower and upper quartiles, n = 20. Data analyzed using a linear mixed model for iAUC and Cmax (fixed factors of treatment, period, treatment × period interaction; random effect of participant; covariate baseline TAG concentrations). NA, not applicable.
n = 19 due to missing sample.
Mean difference is significant (P = 0.043).
Mean difference is significant (P = 0.003).
Mean difference is significant (P = 0.0003).
Pearson χ2 test.