Table 3.
Outcome of salvage HSCT.
| pt | Alive | Whole blood donor chimerism at last f/u | Follow-up (months) | Acute GVHD | Chronic GVHD | Viral reactivation | Viral disease | Other complications | Cause of death | Cessation of immunosuppression (d+) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Yes | 100 | 95 | – | – | CMV, ADV | BK hemorrhagic cystitis | – | n/a | 56 |
| 2 | Yes | 100 | 63 | – | – | – | – | Engraftment syndrome (ARDS), bacteremia (Streptococcus mitis) | n/a | 72 |
| 3 | Yes | 100 | 50 | – | – | – | – | – | n/a | 110 |
| 4 | Yes | 100 | 53 | – | – | – | ADV (enteritis) | – | n/a | 110 |
| 5 | Yes | 100 | 6 | – | – | CMV, ADV | ADV (systemic) | Aspergillosis | n/a | 74 |
| 6 | Yes | 100 | 6 | – | – | ADV, HHV6 | – | Sepsis, toxic nephropathy | n/a | 124 |
| 7 | Yes | 100 | 8 | – | – | CMV | – | Sepsis, colitis (Clostridium difficle) | n/a | 124 |
| 8 | Yes | 100 | 10 | I (skin) | mild (skin) | CMV, HHV6 | Norovirus (enteritis) | Sepsis, deep skin infection (Pseudomonas), | n/a | 252 |
| 9 | Yes | 30–40 | 30 | – | – | CMV | – | Sepsis (Escherichia coli), bacteremia (coagulase-neg. Staphylococcus) | n/a | 228 |
| 10 | Yes | 100 | 21 | – | – | CMV, ADV | – | – | n/a | 92 |
| 11 | Yes | 100 | 37 | – | – | CMV, ADV, BK, HHV6 | BK hemorrhagic cystitis | Sepsis (Enterococcus faecium), fungal skin infection (Trichosporon asahi) | n/a | 100 |
| 12 | No | 100 | 9 | – | – | CMV, ADV | – | Idiopathic pneumonitis (d + 226) treated with etanercept | Death (d + 259) due to CLIPPERS syndrome with intracranial bleeding and consecutive hydrocephalus | 240 |
ADV adenovirus, ARDS acute respiratory distress syndrome, CLIPPERS chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids, CMV cytomegalovirus, HHV6 Human herpesvirus 6.