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Schematic of treatment approach with multifunctional silica–iron oxide nanoparticles (SIO). The SIO increase ultrasound (US) and magnetic resonance imaging (MRI) contrast of human mesenchymal stem cells (hMSCs). They can also increase cell retention via the iron oxide nanoparticles embedded in the silica and an external magnet. Moreover, the SIO improve cell viability with sustained release of insulin-like growth factor (IGF).
