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. Author manuscript; available in PMC: 2021 May 9.
Published in final edited form as: ACS Nano. 2019 Jun 17;13(6):6605–6617. doi: 10.1021/acsnano.9b00653

Figure 6.

Figure 6.

Effects of IGF-loaded SIO-labeled hMSC treatment on cardiac functions and pathological evaluation. (a) Comparison of mean LVEF among four groups (n = 12) from baseline, day 30, and day 60. IGF-loaded SIO-labeled hMSCs significantly increased LVEF and absolute value of global longitudinal strain (GLS) on both day 30 and 60 compared to the baseline. Error bars are standard errors (n = 12); *p < 0.05, **p < 0.005. (b) Change of LVEF on day 60 from baseline for individual subjects. Error bars are standard deviations (n = 12); **p < 0.005 (two-tail and type-two t test was used). (c) Mean GLS of each group (n = 12) from baseline, day 30, and day 60. (d) Photos show frontal view (top row) and transverse view (bottom row) of a representative heart from each group. (e) Mean heart-to-body weight ratio of each group. Error bars are standard errors (n = 11 for hMSC control group and 12 for the other three groups); *p < 0.05, **p < 0.005, ***p < 0.0005. (f) Representative heart slices stained with trichrome staining from each group. Blue indicates fibrosis, and red indicates myocardium. RV: right ventricle. (g) Quantitative analysis for fibrosis. Error bars are standard deviations for six animals.