Figure 5.

Injury-induced neurogenesis and gliogenesis in the postnatal and adult mammalian brain. In the intact brain, NSCs in the VZ-SVZ and DG selectively produce OB interneurons (A) or DG granule cells (B), respectively (blue arrows). In response to various insults, however, those in the VZ-SVZ are thought to produce new neurons and glia (astrocytes and/or oligodendrocytes) that migrate to damaged areas such as the corpus callosum (CC), cerebral cortex (Cx), striatum (St), and hippocampal CA1 region (highlighted in red and green shades), and replace cells lost to insult (red arrows). The exact identity and functional properties of these cells, however, remain poorly understood. Abbreviations are the same as in Figure 1.