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. 2021 May 9;28:36. doi: 10.1186/s12929-021-00732-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — NOTCH1 activation in fibroproliferative skin diseases. Immunohistochemical staining pattern showing the expression levels of the cleaved, biologically active NOTCH1 protein (NICD, Notch intracellular domain) in skin biopsies from patients affected with four different fibroproliferative diseases and normal controls. In general, NICD is constitutively expressed in keratinocytes, endothelial cells and immune cells of patients affected with the various fibroproliferative disorders and healthy biopsies, with no significant variation among them. As for NICD expression in fibroblasts, it was generally low in morphea and barely detected in healthy controls. On the other hand, Notch pathway is activated in fibroblasts from keloids, hypertrophic scars and dermatofibromas. Figure adapted from [149]