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CIU50 stability analysis of KCNQ1 variants. A. Sigmoidal curves are fit between identified features to describe the transition, where WT and R231C have two transitions and E115G and H126L have one transition. B. A bar chart of average CIU50 values extracted from the inflection point determined for each first transition detected, N = 3. Gray is WT, blue is GOF, and red is LOF.
