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. 2021 Jul 13;54(7):1578–1593.e5. doi: 10.1016/j.immuni.2021.05.002

Figure 6.

Figure 6

HLA profile links COVID-19 immunopathology to impaired virus recognition

(A) Correlogram of all immune features (TPs 1 and 2) with ES COVID-19s versus COVID-19m > 0.3, shown for COVID-19s and HAP. Red arrows highlight immune features unique in COVID-19s (ES versus HAP > 0.4). Black boxes 1–3 highlight highly correlating immune clusters.

(B) Correlogram of immune features from TP 1 only with ES COVID-19s versus COVID-19m > 0.3 with HLA score 50. HLA score 50 represents the number of predicted tightly binding SARS-CoV-2 peptides of both HLA alleles of a patient. Red arrows highlight SARS-CoV-2-specific immune features (ES COVID-19s versus HAP > 0.4).

(C) Correlogram of immune features from TP 1 only with ES COVID-19s versus COVID-19m > 0.3 with routinely assessed clinical parameters. Red arrows highlight highly correlating parameters.

(D) Correlation between LDH and granulocyte counts (TP 1 only) against the severity grade of COVID-19 patients.

See also Figure S6.