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. Author manuscript; available in PMC: 2021 May 9.
Published in final edited form as: Anal Chem. 2020 Jul 7;92(14):9830–9837. doi: 10.1021/acs.analchem.0c01328

Figure 1:

Figure 1:

A) HDX rates for the c-terminal isoleucine in peptide YPI measured by NMR at various pD. Solid lines represent fits of exponential decay functions. B) Plot of the log of the exchange rate, log(kex), as a function of pD for both YPI (green) and 1,3-dimethylimidazolium (gray). The slopes (m) of the lines are shown next the linear fit. C) pD dependence of HDX at the C-2 proton for 1,3-dimethylimidazolium measured by NMR at various pD. D) General mechanism for HDX at the C-2 proton for 1,3-dimethylimidazolium.