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. 2021 Apr 27;14(4):dmm047746. doi: 10.1242/dmm.047746

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© 2021. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Phospholipid changes in worms treated with either elo-2 RNAi or mdt-15 RNAi. (A) RNAi of elo-2, which has fatty-acid elongase activity in worms, is expected to increase carbon-chain length of phospholipids. (B) PCA showing clear distinction between elo-2 RNAi-treated worms and control worms (n=6 biological replicates). (C) Changes in the TG composition of elo-2 RNAi versus empty vector controls shows significant decrease of phospholipids with long carbon-chain length (>55) and significant increase of TG species with short carbon-chain length (<55). (D,E) A similar pattern was observed in other phospholipid species such as PC (D) and DG (E). (F) RNAi of mdt-15, a transcription factor upregulating fat-2, fat-5, fat-6 and fat-7, affects the level of unsaturation, i.e. carbon-chain double bonds. (G) PCA showing clear distinction between mdt-15 RNAi-treated worms and control worms. (H) Changes in phospholipids of the TG species show significant decrease of lipids with >2 double bonds and increase of phospholipids with <2 double bonds.