Table 2.

Associations between co-morbid conditions and severe COVID-19 illness.

Co-morbid Condition	All Patients, n (%)	Moderate Illness, n (%)	Severe Illness, n (%)	p-valuea	Adjusted p-valueb
	401	233 (60)	168 (40)
HTN	276 (69)	147 (63)	129 (77)	0.004	0.05
DM	152 (38)	76 (33)	76 (45)	0.02	0.03
Class I or II obesity	133 (34)	75 (33)	58 (25)	0.74	0.39
Class III obesity	69 (17)	41 (18)	28 (17)	0.89	0.14
CKD	96 (24)	43 (18)	53 (32)	0.003	0.07
CHF	65 (16)	30 (13)	35 (21)	0.04	0.11
Cancer	56 (14)	31 (13)	25 (15)	0.76	0.73
Immunocompromised	55 (14)	31 (13)	24 (14)	0.89	0.64
Autoimmune conditionc	27 (7)	15 (6)	12 (7)	0.93
Immunosuppressive therapyd	21 (5)	11 (5)	10 (6)	0.74
Steroid usee	17 (4)	7 (3)	10 (6)	0.23
Recent chemotherapy	13 (4)	7 (3)	6 (4)	1.0
SOT recipient	9 (2)	3 (1)	6 (4)	0.17
HIV	8 (2)	7 (3)	1 (1)	0.15
Stem cell transplant	4 (1)	2 (1)	2 (1)	1.0
CAD	53 (13)	27 (12)	26 (16)	0.33	0.99
Liver Disease	16 (4)	10 (4)	6 (4)	0.92
Hemoglobinopathy	5 (1)	3 (1)	2 (1)	1.0

^aP-values calculated using chi-squared test.

^bAdjusted p-values calculated by controlling for age, sex, and race.

^cAutoimmune conditions included but were not limited to multiple sclerosis, collagen vascular diseases, systemic lupus erythematous, rheumatoid arthritis, multiple sclerosis, Sjojgren's syndrome, inflammatory bowel disease, celiac disease, ankylosing spondylitis, psoriatic arthritis, dermatomyositis, scleroderma, and polymyalgia rheumatica.

^dImmunosuppressive therapies included methotrexate, azathioprine, mTOR inhibitors (tacrolimus, serolimus, everolimus), cyclosporine, mycophenolate, and immunosuppressive monoclonal antibodies.

^eIncluded use of ≥10mg prednisone or the equivalent corticosteroid.

Abbreviations: HTN = hypertension; DM = diabetes mellitus; CKD = chronic kidney disease; CHF = congestive heart failure; SOT = solid organ transplant; CAD = coronary artery disease