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. 2021 May 5;13:3629–3637. doi: 10.2147/CMAR.S281690

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© 2021 Li et al.

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Overexpression of circ_POLA2 suppress the maturation of miR-34a in AML cells. The expression of circ_POLA2 was detected in human bone marrow stromal HS-5 cells and two human AML cell lines (A). To explore the role of circ_POLA2 in the maturation of miR-34a, Kasumi-6 and Kasumi-3 cells were transfected with either circ_POLA2 expression vector or miR-34a mimic. Expression of circ_POLA2 and mature miR-34a expression was determined every 24 h until 144 h (B and C). The effects of circ_POLA2 expression vector transfection on the expression of mature miR-34a (D) and the expression of miR-34a precursor at each time point (E), as well as the effects of miR-34a mimic transfection on the expression of circ_POLA2 (F) were analyzed by RT-qPCR. *p < 0.05.