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. 2021 May 5;13:3629–3637. doi: 10.2147/CMAR.S281690

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© 2021 Li et al.

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Overexpression of PD-L1 rescued the effect of knockdown of circ_POLA2. BrdU assay was performed to further confirm the role of circ_POLA2 and miR-34a (A). The role of circ_POLA2 in regulating the expression of PD-L1 was analyzed by Western-blot (B). The expression of PD-L1 mRNA in BM samples were also analyzed RT-qPCR. Pearson’s correlation coefficient was performed to analyze the correlation between circ_POLA2 and PD-L1 mRNA across BM tissues from AML patients (C). Cell cycle was measured by flow cytometric analysis (D). CDK4, CDK6 protein levels were measured by Western blot in Kasumi-6 and Kasumi-3 cells (E). *p < 0.05.