Naymagon et al.3
|
50/Male |
10.6% |
Hydroxychloroquine, Azithromycin, Ceftriaxone |
Methylene blue Ascorbic acid |
Patient required intensive care, was intubated and required vasopressors |
MethHb levels normalized by Day 11 of hospitalization, patient got extubated, was still hospitalized |
Naymagon et al.3
|
52/M |
>30% |
Hydroxychloroquine, Azithromycin, Cefepime, Cancomycin |
Methylene blue Ascorbic acid Red cell exchange |
Patient required intensive care, was intubated, required vasopressors, developed ARF mandating renal replacement therapy |
Improved clinically with a complete normalization of Met‐Hb level. Patient remains critically ill, ventilated and on vasopressors (Still hospitalized at the time of write up of case) |
Naymagon et al.3
|
54/M |
18.8% |
Hydroxychloroquine, Azithromycin |
Methylene blue |
Patient's laboratory suggested worsening hemolysis once started on methylene blue. Patient's Met‐Hb worsened from 13.6% to 18.8%. A new diagnosis of G6PD deficiency was found concurrent to methemoglobinemia. Direct antiglobulin test was negative. |
The patient died shortly after admission. |
Faisal et al.8
|
74/M |
15.9% |
Azithromycin, Hydroxychloroquine, Lopinavir-ritonavir, Ribavirin, Tocilizumab |
Intravenous hydroxocobalamin Methylene blue Ascorbic acid Red cell exchange |
Patient required prolonged intensive care (4 weeks), was intubated, developed ARF requiring renal replacement therapy |
After prolonged ICU course, patient recovered, got extubated, RRT frequency went down and was discharged to rehabilitation. |
Palmer et al.5
|
62/M |
6.5% |
Amoxicillin/clavulanic acid, Folic acid |
None |
Patient required high flow oxygen and renal replacement therapy. Direct antiglobulin test was negative G6DP assay confirmed G6DP deficiency |
Prolonged duration of stay, was discharged after 22 days of hospital stay. |
Lim et al.6
|
39/M |
14.8% |
Hydroxychloroquine |
Ascorbic acid Red cell exchange |
Patient required high flow oxygen and renal replacement therapy G6DP assay confirmed G6DP deficiency |
Improved, discharged home |
Choo et al.4
|
52/M |
30% |
Hydroxychloroquine, Azithromycin |
Methylene blue Ascorbic acid Red cell exchange |
Patient required intensive care, was intubated, required vasopressors, renal replacement therapy. There was a rapid fall in hemoglobin requiring 12 units of PRBCs support |
Hemolysis resolved; methemoglobin levels improved. The patient was on vasopressors at the time writing up of case. |
Kuipers et al.7
|
56/M |
9.1 |
Hydroxychloroquine |
Ascorbic acid |
Patient required intensive care, was intubated. G6DP assay confirmed G6DP deficiency. There was a rapid fall in hemoglobin requiring 3 units of PRBCs support |
Improved, discharged home |