Table 1.

Correlation Between the Epithelial Expression of COL5A2 and Clinicopathological Variables in Patients with Colorectal Cancer Revealed by Immunohistochemistry Analysis of a Tissue Microarray

Clinicopathological Parameters	Full Tissue Spot		χ2	p	Epithelia		χ2	p	Stroma		χ2	p
	< M	> M			< M	> M			< M	> M
Gender
Male	47	44	0.049	0.826	47	44	0.611	0.4344	48	44	0.3644	0.5461
Female	44	44			37	44			40	44
Age
<70	47	41	0.458	0.499	48	38	4.137	0.042	44	44	0.0486	0.8255
≥70	44	47			36	53			44	47
Grade
I	4	4	1.437	0.488	5	3	1.748	0.4173	3	5	0.5961	0.7423
II, I–II	58	63			51	50			50	53
III, I–III, II–III	29	21			28	38			35	33
T
T1-T2	11	4	8.491	0.014	11	4	4.337	0.0373	7	8	1.331	0.5139
T3	72	64			71 (T3+T4)	86 (T3+T4)			71	65
T4a T4b	7	18							10	15
N
N0	55	55	0.192	0.909	52	56	0.052	0.9744	50	60	1.82	0.4025
N1a N1b N1c	26	25			23	26			29	22
N2a N2b	10	8			9	9			9	9
AJCC 7th stage
1	10	3	4.432	0.109	9	4	2.894	0.2352	7	6	1.871	0.3924
2A 2B 2C	44	51			41	52			43	52
3A 3B 3C 4A 4B	36	32			32	36			38	30
Tumor size
<50 cm2	64	61	0.34	0.844	60	61	0.12	0.9417	62	63	0.1201	0.9417
50–150 cm2	11	9			10	10			10	10
≥150 cm2	16	18			14	20			16	18
Positive lymph node
0	53	48	9E-04	0.976	52	48	0.292	0.5887	48	53	0.6207	0.4308
1~12	35	32			31	34			36	31

Note: The protein expression of COL5A2 was dichotomized into low and high groups using the median (M) value as the cutoff.