. 2021 May 5;14:2991–3002. doi: 10.2147/OTT.S288422

Table 2.

Univariate and Multivariate Analyses of Clinicopathological Variables for the Disease-Free Survival and Overall Survival of CRC Patients

	Univariate							Multivariate
	β	SE	Wald	Sig.	Exp (β)	95.0% CI for Exp (β)		β	SE	Wald	Sig.	Exp (β)	95.0% CI for Exp (β)
	β	SE	Wald	Sig.	Exp (β)	Lower	Upper	β	SE	Wald	Sig.	Exp (β)	Lower	Upper
1. Oncomine gene expression dataset analysis^a
DFS
Age	0.003	0.008	0.116	0.733	1.003	0.986	1.020
COL5A2 mRNA	0.475	0.226	4.432	0.035	1.608	1.033	2.503
Grade	0.692	0.230	9.062	0.003	1.997	1.273	3.133
Recurrence	2.272	0.293	60.110	0.000	9.703	5.463	17.235	2.113	0.299	49.839	0.000	8.276	4.603	14.882
Sex	0.051	0.222	0.052	0.819	1.052	0.681	1.626
Stage	0.985	0.141	48.820	0.000	2.677	2.031	3.528	0.429	0.197	4.742	0.029	1.536	1.044	2.259
OS
Age	0.006	0.009	0.472	0.492	1.006	0.988	1.025
COL5A2 mRNA	0.697	0.247	7.984	0.005	2.008	1.238	3.257	0.677	0.344	3.876	0.049	1.969	1.003	3.863
Grade	0.695	0.241	8.311	0.004	2.004	1.249	3.215
Recurrence	1.569	0.308	25.958	0.000	4.801	2.625	8.778	1.293	0.317	16.592	0.000	3.644	1.956	6.788
Sex	0.100	0.237	0.176	0.675	1.105	0.694	1.759
Stage	1.049	0.154	46.482	0.000	2.854	2.111	3.859	0.448	0.219	4.180	0.041	1.565	1.019	2.404
2. Immunohistochemistry of a TMA^b
OS
Age	0.520	0.240	4.706	0.030	1.682	1.051	2.689	0.663	0.252	6.912	0.009	1.94	1.184	3.181
Sex	−0.068	0.212	0.102	0.750	0.935	0.617	1.416
Positive lymph node	0.940	0.213	19.406	0.000	2.560	1.685	3.888
T	0.429	0.189	5.160	0.023	1.535	1.061	2.222
N	0.833	0.143	33.770	0.000	2.301	1.737	3.048	0.964	0.157	37.850	0.000	2.623	1.929	3.566
M	1.415	0.590	5.749	0.016	4.115	1.295	13.077
AJCC 7th staging	0.901	0.172	27.368	0.000	2.462	1.756	3.450
Grade	0.864	0.274	9.940	0.002	2.373	1.387	4.062	0.583	0.247	5.565	0.018	1.791	1.104	2.905
Tumor size	0.555	0.234	5.643	0.018	1.742	1.102	2.755	0.578	0.245	5.577	0.018	1.782	1.103	2.879
Epithelial COL5A2	0.687	0.260	6.962	0.008	1.987	1.193	3.309	0.574	0.262	4.792	0.029	1.776	1.062	2.969

Notes: ^aThe analysis was performed using the Smith Colorectal dataset from the Oncomine cancer gene expression microarray DB (https://www.oncomine.org/resource/login.html). ^bThe analysis was based on the immunohistochemistry assay of a tissue microarray (HCol-Ade180Sur-04) containing 90 pairs of CRC and matched normal tissues.

Abbreviations: OS, overall survival; DFS, disease-free survival; b, beta coefficients; SE, standard error for each parameter estimate; Wald, Wald statistic; Sig., significance; Exp, the exponentiated parameter estimates; CI, confidence interval.