Why carry out this study?

Eribulin mesylate was approved by the Food and Drug Administration ten years ago for the treatment of patients with metastatic breast cancer (MBC), who had previously received at least two chemotherapy regimens for MBC, including an anthracycline and a taxane in the adjuvant or metastatic setting. The treatment landscape for MBC evolved dramatically over the past decade, so up-to-date real-world effectiveness data of eribulin is valuable when used according to the approved US indication in clinical practice.

We sought to investigate clinical effectiveness of eribulin therapy in a large, diverse cohort of patients with MBC in real-world clinical practice, including a subgroup of patients with triple negative breast cancer (TNBC), treated in accordance with the approved indication for eribulin in the United States.

What was learned from the study?

In a cohort of 513 MBC patients treated with eribulin, ORR was 54.4%, median PFS was 6.1 months, and median OS was 10.6 months. Within the TNBC subtype, ORR was 55.5%, median PFS was 5.8 months, and median OS was 9.8 months.

The present study reinforces the clinical effectiveness of eribulin in a large, heterogeneous patient population in clinical practice over the past decade, when used consistent with the approved US indication in the overall MBC population as well as within the TNBC subtype.