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. 2021 Mar 23;38(5):2339–2352. doi: 10.1007/s12325-021-01660-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 1 — Study design. *Clinical responders defined as ≥ 30% decrease from baseline in average daily very soft/liquid stool frequency OR ≥ 30% decrease from baseline in average daily abdominal pain score, and neither worse than baseline. ^†Upadacitinib 6-mg BID dosage initiated and randomization for upadacitinib 24-mg QD dosage stopped with those currently enrolled at 24 mg QD continuing treatment per protocol amendment. BID twice daily; HRQOL health-related quality of life; QD once daily