FIGURE 2.

Exacerbated K/BxN serum arthritis in the absence of Il‐22. A, Clinical score (expressed in arbitrary units, AU) and B, ankle swelling (in mm). Cytokine expression in the synovium C, IL‐6 (in pg/mL), D, CXCL1 (in pg/mL), E, MPO (in ng/mL) and F, IL‐10 (in pg/mL) at day 6. G, Representative histological pictures of the joint following K/BxN serum transfer in wild type (C57Bl/6) and Il‐22 KO animals. H, Inflammation and bone erosion scores (in arbitrary units, AU) quantified from histological analysis at day 10. Mean values +/− standard deviation are shown (n = 8 to 10 mice/group). Representative data from two independent experiments are shown. Data were analysed following a Mann‐Whitney U test. *P <.05**P <.01***P <.001. AUC: area under the curve