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A model integrating ILC3 in serum‐dependent acute arthritis. The cartoon illustrates that complement‐dependent inflammation triggered by anti‐glucose‐6‐phosphate isomerase (G6PI) antibodies/G6PI immune complexes activate cells of the synovial membrane. In response, the cells secrete chemokines such as CXCL1 and CXCL16 attracting neutrophils and ILC3s. Once activated, ILC3 secrete IL‐22 which dampens inflammation and neutrophil recruitment
