FIGURE 3.

GDF11 attenuated pathological features in the TAD mice model. (A) SDS‐PAGE of recombinant GDF11. (B) Effect of GDF11 on BAPN/Ang II‐induced mice mortality. (C) The rate of interlayer formation in mice with TAD. (D) Representative pictures of aortas from mice treated with BAPN/Ang II and GDF11 for 4 wk and thoracic aorta diameter detected by colour Doppler ultrasonography (H). H&E staining (E) EVG staining (F) and Masson staining (G). (I) Elastin degradation score was calculated in TAD mice. Scale bar, 200 μm. Data are presented as mean ± SD (n = 6‐10). **P < .01 vs control group, ^## P < .01 vs TAD group